Thrombus formation and propagation depend on the presence of abnormalities of blood flow, blood vessel wall, and blood clotting components, known collectively as Virchow's triad. Contribution of bone marrow-derived cells - Increase in tissue mass that results from the excess ... Gene on chromosome 21 carries gene for amyloid protein ... May revolve around amyloid protein ... - General Principles of Pathophysiology Energy Metabolism Perfusion Shock Topics Define shock in terms of cellular function Review the requirements for adequate ... Pathophysiology of vascular tone. How- INTRODUCTION : Venous thromboembolism (VTE) A condition in which a blood clot (thrombus) forms in a vein, which in some cases then breaks free and enters the circulation as an embolus, finally lodging in and completely obstructing a blood vessel, e.g., in lungs causing a PE (PULMONARY EMBOLISM) The most common type of venous thromboembolism is DEEP VEIN THROMBOSIS… Or use it to upload your own PowerPoint slides so you can share them with your teachers, class, students, bosses, employees, customers, potential investors or the world. Thrombosis is the leading cause of death in developed countries, impacting a broad range of common medical disorders including diabetes, obesity, myocardial infarction, stroke, and pulmonary embolization. •Smoking is a major risk factor and is thought to account for the recent increase in the incidence and severity of AS in women. Many of them are also animated. Cancer- Associated Thrombosis CAT - . Pathogenesis of Venous Thrombosis Venous thromboembolism, ie, venous thrombosis and pulmonary embolism, represents a serious and potentially fatal complication for many sick, hospitalized patients, especially those who are bedridden for extended periods of time. Some DVTs may cause no pain, whereas others can be quite painful. (u.k) dept of general surgery al mouasat. doi: 10.17226/20259. Genetics. USE PRECAUTION WITH GP IIB/IIIA INHIBITORS, HIGHER RISK OF SIDE EFFECTS WITH PTS 75 YEARS OF, 50 MG VIAL WITH ONE 10 ML VIAL OF STERILE WATER, MUST BE RECONSTITUTED, THEN USED IMMEDIATELY. Thrombosis.Washington, DC: The National Academies Press. Clearance of activated coagulation factors by the liver; 6. If so, share your PPT presentation slides online with PowerShow.com. Prof. J. Plevkova MD, PhD. • Thrombosis is the activation of hemostasis at an inappropriate time and in an inappropriate blood vessel. blood components - platelets. •Lowering cholesterol, especially LDL-C (so called “bad cholesterol”), is clearly a good thing. outline. •Inverse relationship between symptomatic AS and high-density lipoprotein (HDL or HDL-C) levels. Pathophysiology%20of%20acute%20and%20chronic%20renal%20failure. HDL partakes in reverse transport of cholesterol presumably from atherosclerotic plaques. Arterial hypertension. The three factors include: venous stasis, activation of blood coagulation, and vein damage. To view this presentation, you'll need to allow Flash. Macrocytic-Normochromic (Megaloblastic) Most common type ... - ... Hydrothorax Hydropericardium Hydroperitoneum is also called Ascites Massive generalized edema is called Anasarca Fluid Homeostasis Edema Fluid = TRANSUDATE ... Thrombosis and Thrombolysis in Acute Coronary, GP Ia binds platelets to collagen fibers, GP Ib - binds platelets to von Willebrand factor, GP IIb/IIIa - binds platelets to von Willebrand, Prothrombin is a plasma protein that, when. Risk Factors (cont’d) •Hyperlipidemiais acknowledged to be a major risk factor for AS. A solid understanding of the pathophysiology of blood coagulation is essential in the practice of both medicine and surgery. Pathogenesis of Antiphospholipid Antibodies in Pregnancy - . And they’re ready for you to use in your PowerPoint presentations the moment you need them. •Thrombosis occurs when there is a breakdown in the balance between thrombogenic factors and protective mechanisms. Thrombosis - . With prompt diagnosis and treatment, the majority of DVT’s are not life threatening. Create stunning presentation online in just 3 steps. Stent thrombosis: evidence from a network meta-analysis - . SUPER FICIAL BLEEDING OR SURFACE BLEEDING, PTS ROUTINELY TREATED WITH ASA AND HEPARIN. The first step in COVID-19 pathogenesis is viral invasion via its target host cell receptors. •This is called the “response-to-injury hypothesis”. Well-defined familial predisposition such as hypertension and diabetes. causes. Venous thromboembolism (VTE), which includes DVT and pulmonary embolism (PE), affects an estimated 1 per 1,000 people and contributes to 60,000–100,000 deaths annually. Condition. 6. •Virchow's triad (1845) postulated that thrombosis results from alterations in vessel wall, blood flow, and properties of blood. - SHOCK , PATHOPHYSIOLOGY Prof.M.H.MUMTAZ. outline. Risk Factors (cont’d) •Diabetes mellitus induces hypercholesterolemia. Thrombosis. Suggested Citation:"THE PATHOGENESIS OF THROMBOSIS. Here is occlusive coronary atherosclerosis. Atherosclerosis is the development of plaques, or fatty hardenings, on the inner wall of … frans naude. HMG-CoA (3-Hydroxy-3-methylglutaryl-CoA) Lovastatin Statins (cont’d) •One of the drugs used today is shown below next to HMG-CoA: Lipids from diet Chylomicrons Remnants Lipoprotein lipase VLDL Peripheral cell Remnants LDL-R Cholesterol LDL LRP LDL-R Hepatic lipase Cholesterol Cholesterol-ester Transport protein Bile acids Cholesterol HDL Liver Statins (cont’d), Lipids from diet Chylomicrons Remnants Lipoprotein lipase VLDL Peripheral cell Remnants LDL-R Cholesterol LDL LRP LDL-R Hepatic lipase Cholesterol Cholesterol-ester Transport protein Bile acids Cholesterol HDL Liver Statins (cont’d). Arterial Thrombosis Venous. Clinically significant disease rises with each decade, even into advanced age. SHOCK , PATHOPHYSIOLOGY Prof.M.H.MUMTAZ. •Atherosclerosis often produces ischemia of the intestines and lower extremities, and it is a major cause of aortic aneurysms that can rupture to produce fatal hemorrhage. Arterial hypertension Ph. That's all free as well! •Characterized by plaques called atheromasthat protrude into the lumen, weaken the underlying media, and undergo a series of complications that predispose to overlying thrombosis. Turbulence contributes to arterial and cardiac thrombosis by causing endothelial injury or dysfunction, as well as by forming countercurrents and local pockets of stasis; stasis is a major contributor in the development of venous thrombi. Coronary artery with mild atherosclerosis and some fatty streaks. samar abu ouda 20060282. pathogenesis & immunopathogenesis. Females are sheltered from disease from AS until menopause. Deep vein thrombosis can cause leg pain or swelling, but also can occur with no symptoms.Deep vein thrombosis can develop if you have certain medical conditions that affect how your blood clots. • Formation of a blood clot in an artery or vein of a living person • Arterial thrombosis denies oxygen and nutrition to an area of the body. Atherosclerosis--Basic Mechanisms (cont’d) •This suggests that lesions of atherosclerosis represent a specialized form of a protective, inflammatory (“fibroproliferative”) response to forms of insult to the artery wall. This plaque can suddenly burst (rupture), followed by a blood clot. Point of intervention Smoking Blood pressure Cholesterol Obesity Other factors Risk Thrombosis Heart attack Management and Prevention (cont’d). - Pathophysiology of digestion MD, Prof. Yu.I. In brief, SARS-CoV-2 consists of four main structural glycoproteins: spike (S), membrane (M), envelope (E), and nucleocapsid (N). academic day - medical oncology jan 28, 2011. armand trousseau 1801-1867. Chronic inflammatory response featuring monocytes and T-lymphocytes. Clinically, the role of vessel wall damage in the pathogenesis of venous thrombosis is uncertain at this time, but immobility plus increased coagulability is recognized as a major risk factor. "National Research Council. They'll give your presentations a professional, memorable appearance - the kind of sophisticated look that today's audiences expect. Pathogenesis of Thrombosis. definition. It's FREE! Statins (cont’d) Adverse effects- •The most common adverse effects of statins are gastrointestinal upset, muscle aches, and hepatitis. Fatty streaks in a relatively normal adult aorta. Pulmonary embolism (PE) occurs when there is an acute obstruction of the pulmonary artery or one of its branches. department of neurosciences canberra hospital march 1999. cerebral venous, chapter 32 Viral Pathogenesis - . definition . formation of a clot within a vein occurs when there is i ) venous stasis ii)vessel injury, Discuss the pathogenesis and imaging approach of acromegaly and gigantism - . A coronary thrombosis is seen microscopically occluding the remaining small lumen of this coronary artery. •Reducing thrombotic potential is an effective way of preventing the onset or recurrence of clinical events regardless of risk factors. Pathogenesis of Atherosclerosis Judith Berliner, Ph.D. COVID-19 infection is associated with high morbidity and mortality largely due to respiratory failure, with microvascular pulmonary thrombosis or PE originating from the leg veins playing an additional important pathophysiological role. Entamoeba histolytica Pathogenesis and pathology - . Viral Pathogenesis - . ( 1) mechanisms on placental cell ( i ) thrombosis ( a), Deep Vein Thrombosis (DVT) - . •Atherosclerosis is from the Greek words, refers to the thickening of the arterial intima (sclerosis, “hardening”) and accumulation of lipid (athere, “gruel”) that characterize the typical lesion. Atherosclerosis (cont’d) •It is a disease of the arterial intima leading to the formation of fibrous (“atheromatous”) plaques- proliferation of smooth muscle cells and the accumulation of lipids. •Complications of atherosclerosis (myocardial infarction, stroke and peripheral arterial ischemia) can be reduced: --by not smoking, --by treating hypertension, --by reducing cholesterol, and --by increasing physical activity. •Hepatitis — fatigue, sluggishness, anorexia, and weight loss — resemble those of an influenza-like syndrome. Deep vein thrombosis: pathogenesis, diagnosis, and medical management Deep vein thrombosis (DVT) is a major preventable cause of morbidity and mortality worldwide. incidence pathogenesis predisposing, Deep Venous Thrombosis and its Complications - . The APEX Trial Investigators; Associate Editor(s)-in-Chief: Rim Halaby, M.D. objectives. Thrombosis/thrombophilia patients captured at HTCs participating in ATHN - . PPT – Pathophysiology of Thrombosis PowerPoint presentation | free to download - id: 3d624e-Y2QzZ, The Adobe Flash plugin is needed to view this content. presentations for free. •Statins lower serum LDL-C concentrations by up-regulating LDL-receptor activity and by reducing entry of LDL into the circulation. Sex.Males are much more prone to AS than females. The coronary at the right is even worse with evidence for previous thrombosis with organization of the thrombus and recanalization such that there are three small lumens remaining. •Virchow's triad (1845) postulated that thrombosis results from alterations in vessel wall, blood flow, and properties of blood. division of critical care medicine university of alberta. “Response-to-Injury Hypothesis” for Development of Atherosclerosis 7. These have thin fibrin caps that are prone to rupture. There is overlying recent hemorrhage at the left. Do you have PowerPoint slides to share? Statins •Inhibit 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase •Catalyzes conversion of HMG-CoA to mevalonate, an early step in the synthesis of cholesterol– a rate-limiting step in cholesterol production. Pathophysiology of Thrombosis Thrombosis and Thrombolysis in Acute Coronary Syndromes Blood Components - Platelets Contain adhesive glycoproteins GP Ia binds ... – A free PowerPoint PPT presentation (displayed as a Flash slide show) on PowerShow.com - id: 3d624e-Y2QzZ 5 PREVENTION AND MANAGEMENT OF THROMBOSIS IN LIVER DISEASES. The antiphospholipid syndrome (APS) is an important cause of acquired thrombophilia. 1865: Molecular pathogenesis of subarachnoid haemorrhage - . “Response-to-Injury Hypothesis” for Development of Atherosclerosis 1. – Thrombosis of an artery leading to the heart causes a myocardial infarction – Thrombosis of an artery leading to the brain causes a stroke. J Thromb Haemost 2010; 8: 1886–94. Venous thromboembolism (VTE), a disease that includes deep venous thrombosis (DVT) and pulmonary embolism (PE), is associated with high mortality, morbidity, and costs. Thrombosis: The Critical Role of the Lab Paul Riley, PhD, MBA, Diagnostica Stago, Inc. Learning Objectives Describe the basic pathophysiology of DIC Demonstrate a diagnostic and management approach for DIC Compare markers of thrombin & plasmin generation in DIC, including D-Dimer, A blood clot is formed in a blood vessel, obstructing blood flow. •Atherosclerosis affects large and medium-sized arteries. Deep Vein Thrombosis - . Disseminated intravascular coagulation (DIC) - . Departments of Pathology and Medicine Division of Cardiology David Geffen School of Medicine at UCLA – A free PowerPoint PPT presentation (displayed as a Flash slide show) on PowerShow.com - id: 3f4967-MzFiM Pathophysiology of DVT Virchow’s triad was developed to help identify the factors that were present in those patients who were developing DVTs. baiping zhang, kaare gugleholm, lorna b. day, shu ye, roy o. Thrombus may form on top of such a plaque. basic skeletal structures & functions. In The Most Common Inpatient Problems in Internal Medicine, 2007. •Vessel wall •Blood flow •Properties of blood Arterial Thrombosis Venous Rudolf Virchow Pathogenesis of Thrombosis •Thrombosis is the activation of hemostasis at an inappropriate time and in an inappropriate blood vessel. Examples of Atherosclerosis of Human Arteries Microscopically, the aortic atheromatous plaque is thicker than the remaining media at the right. •Vessel wall •Blood flow •Properties of blood Arterial Thrombosis Venous Rudolf Virchow Pathogenesis of Thrombosis •Thrombosis is the activation of hemostasis at an inappropriate time and in an inappropriate blood vessel. Neutralization of activated coagulation factors by naturally occurring protease inhibitors; 4. Editor-In-Chief: C. Michael Gibson, M.S., M.D. •If we have these deposits of cholesterol, the lipoproteins are modified, and so forth and so forth. 3. The nonthrombogenic properties of intact endothelium; 2. Pathogenesis of Thrombosis (cont’d) The protective mechanisms are: 1. Pathophysiology. This can lead to a buildup of fatty material (called plaque) in the artery walls. D., M D. Nataliya Potikha Regulation of arterial pressure ( P) CO leads to PR and P ... - Title: Neurological Pathophysiology Author: Yu Last modified by: Yu, Min Created Date: 2/10/2004 2:52:52 PM Document presentation format: On-screen Show (4:3). jørn dalsgaard nielsen thrombosis centre gentofte hospital denmark. Pathophysiology of liver, - Title: Pathophysiology of digestion Author: User Last modified by: User Created Date: 1/7/2012 8:47:06 AM Document presentation format: (4:3), VASCULATURE, HEMODYNAMICS AND THEIR PATHOPHYSIOLOGY. - Clinical pathophysiology of the digestive system Clinical syndromes in liver injury Lack of liver disorders ... (involved in carbohydrate, fat, protein ... PATHOPHYSIOLOGY of TOBACCO-RELATED DISEASE, - pathophysiology of tobacco-related disease, Pathophysiology of acute and chronic renal failure, - Pathophysiology of acute and chronic renal failure Renata P ov, - PATHOPHYSIOLOGY OF BURNS Dr. Shiara Ortiz-Pujols Burn Fellow NC Jaycee Burn Center, Pathophysiology of digestion. Abnormalities of blood flow or venous stasis normally occur after prolonged immobility or confinement to bed. Tissue factor is a substance present in tissue, Blocks conversion of prothrombin to thrombin, LOWER MORTALIT RATE WITH TPA VERSUS STREPTOKINASE, HIGHER RISK OF INTRACRANIAL BLEEDING WITH TPA, DOSE- INITIAL BOLUS OF 15 MG IV, THEN 0.75 MG/KG, NO CHANGE ON MORTALITY COMPARED TO STREPTOKINASE, DOSE- 10 UNITS GIVEN OVER 2 MIN THEN REPEATED, THIRD GENERATION VARIANT OF THE t-PA MOLECULE, RESISTANCE TO PLASMINOGEN ACTIVATOR INHIBITOR, TNKASE BINDS TO FIBRIN AND CONVERTS PLASMINOGEN, THROMBOLYTIC THERAPY CLASS IF CLINICAL COMPLAINTS, DOOR TO DRUG TIME GOAL lt THAN 30 MINUTES, CONSIDERED CLASS II a IF PATIENTS GREATER THAN 74, INTRACRANIAL OR INTRASPINAL SURGERY WITHIN 2, RECENT ADMINISTRATION OF GP IIB/IIIA INHIBITORS. Learn about the symptoms and treatment of this condition. Management and Prevention •Antithrombotic medication now forms an important part of the management and prevention of: -ischemic heart disease (IHD); -stroke; -and other vascular conditions. Thrombotic events, including venous thrombosis and portal vein thrombosis are frequent in patients with cirrhosis. Genetic derangements in lipoprotein metabolism, prototype is familial hypercholesterolemia. Atherosclerosis •No disease in the U.S. is responsible for more deaths and has engendered more controversy than atherosclerosis (AS). Portal vein thrombosis (PVT) is a blood clot that causes irregular blood flow to the liver. Pathophysiology of Thrombosis - . Thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS) are acute thrombotic microangiopathies (TMAs) characterized by acute episodes of intravascular hemolysis, thrombocytopenia and microvascular thrombosis leading to end‐organ damage becoming apparent as acute kidney injury, cerebrovascular accidents or seizures, and myocardial … By: Dr. Malak El-Hazmi Dr. Abdulkarim Alhetheel - Introduction to medical virology “ viral pathogenesis”. 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